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Join a study.
Help find a cure.

Every medical breakthrough we celebrate and benefit from is because of volunteers just like you. Everyday people who say “yes” to participating in clinical trials are changing the world for the better.

Explore our open studies — each one represents an opportunity to help build healthier futures.

Select a condition
to view the relevant open studies

Additional Filters

Alcohol Use Disorder

Alcohol Use Disorder (AUD) is a medical condition characterized by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. Symptoms can include an intense craving for alcohol, the inability to limit drinking, and continuing to use alcohol even when it causes physical or psychological problems. 

Preliminary Qualifications

  • You are able to travel to the research center in Orlando, FL.
  • You are 21-75 years of age.
  • You have a BMI ≥ 22.
  • You have a history of alcohol use, with an average alcohol intake ≥ 20 standard alcohol drinks per week for males and ≥ 10 standard alcohol drinks per week for females.
  • Your current alcohol consumption reflects your alcohol intake for at least the previous 12 months.
Get involved

Bipolar Disorder Study

Bipolar disorder is a brain disorder causing extreme mood swings or episodes, including emotional highs and severe lows. These shifts affect energy, activity, sleep, and clear thinking. Using a brand new GLP-1 injection, this study is looking to possibly extend the stable, non-symptomatic time between mood episodes. 

Preliminary Qualifications

  • You are able to travel to the research center in Orlando, FL.
  • You have a diagnosis of Bipolar Disorder.
  • You are 18-75 years of age.
  • You are able to self-administer the subcutaneous GLP-1 study drug.
  • Have had 3 or more total lifetime mood episodes (including most recent episode), such as major depressive episode, mania, hypomania, or episode with mixed features (per investigator assessment).
Get involved

Free Liver Screen

Metabolic liver disease is a growing concern affecting a significant portion of the population. This condition causes excess fat buildup in the liver, leading to inflammation and potential scarring. A FREE liver screen can check if you have indicators for liver disease.

Preliminary Qualifications

  • You are 18+ years of age.
Get involved

Alcohol Associated Liver Disease Study

Chronic, heavy alcohol consumption is the leading cause of Alcohol-Associated Liver Disease (ALD). This trial will examine the effects of GLP-1s on treating the liver damage seen in patients with ALD, as well as the ability to reduce alcohol cravings.

Preliminary Qualifications

  • You are able to travel to the research center in Orlando, FL.
  • You are 18-75 years of age.
  • You have a BMI ≥ 25.
  • You have a history of alcohol misuse for the prior 3 years through the time of screening, with an alcohol intake ≥ 3.5 standard alcohol drinks per day for males and ≥ 2.5 standard alcohol drinks per day for females, on average in the past year.
  • Your alcohol consumption pattern reflect the participant’s average monthly alcohol intake, sustained for a minimum period of 12 months, as determined through participant self-report and investigator’s clinical judgment.
Get involved

Free Memory Screen

A memory screen is a brief, simple test used to evaluate a person's memory and other cognitive functions, like language skills and thinking ability.

Preliminary Qualifications

  • You have the ability to consent to the test.
Get involved

Parkinson’s Disease Study

Parkinson’s disease is a slowly progressive and disabling neurodegenerative disease manifesting with motor issues, such as tremor, muscle rigidity, and slowed movement. This study drug is being developed as a potential disease-modifying treatment for Parkinson’s disease, possibly slowing progression.

Preliminary Qualifications

  • You are able to travel to the research center in Orlando, FL or The Villages, FL.
  • You are 40-85 years of age.
  • You have a BMI between 18-34.
  • You have been diagnosed with Parkinson's disease.
Get involved

Alcohol Overuse Liver Disease Study

Chronic, heavy alcohol consumption is the leading cause of Alcohol-Associated Liver Disease (ALD). This trial will examine the effects of GLP-1s on reducing alcohol cravings, as well as treating the liver damage seen in patients with ALD.

Preliminary Qualifications

  • You are able to travel to the research center in Orlando, FL.
  • You are 18-75 years of age.
  • You have a BMI ≥ 25.
  • You have a history of alcohol overuse for the prior 3 years through the time of screening, with an alcohol intake ≥ 3.5 standard alcohol drinks per day for males and ≥ 2.5 standard alcohol drinks per day for females, on average in the past year.
Get involved

Clinical Depression Study

This is a Phase 3 clinical trial, evaluating a new investigational drug for treating clinical depression—also called Major Depressive Disorder (MDD)—in adults. This research is significant because it explores the potential to provide a rapid and durable treatment option for the millions of people living with clinical depression.

Preliminary Qualifications

  • You are able to travel to the research center in Orlando, FL.
  • You have a diagnosis of Clinical Depression/Major Depressive Disorder (MDD) based upon clinical assessment.
  • You are currently experiencing a major depressive episode (MDE) of ≥8 weeks and ≤24 months duration.
  • You have experienced at least one depressive episode before the current episode.
Get involved

Early Alzheimer’s Study

The purpose of this early Alzheimer's study is to find out if the study drug can possibly prevent, delay, or slow early symptoms of Alzheimer’s disease.

Preliminary Qualifications

  • You are able to travel to the research center in Chicago, IL.
  • You are 55–85 years of age.
  • You have a diagnosis of mild- to moderate-Alzheimer's disease.
  • You can swallow capsules
Get involved

Alzheimer’s-Related Anxiety & Restlessness Study

Alzheimer's-related anxiety & restlessness—from finger tapping, nail biting and restlessness to excessive motor activity, verbal aggression, or even physical aggression—is particularly challenging because there are currently no effective treatments for it.

Preliminary Qualifications

  • You are able to travel to the research center in Orlando, FL or The Villages, FL.
  • The potential study volunteer is 55+ years of age.
  • There is a confirmed high likelihood of Alzheimer's disease, using either a blood-based biomarker or cerebrospinal fluid biomarker.
  • Any of the following are present (or similar traits not listed): pacing, rocking, restlessness, yelling, repetitive motor activity, scratching, slamming doors, finger tapping, or kicking objects.
  • Anxiety, restlessness, & agitation is not solely attributable to another psychiatric, medical, or environmental condition.
Get involved

Alzheimer’s Biomarker Study

Imagine your body is like a car, and you want to know how it's running. A biomarker is like a gauge or a warning light on the dashboard, something measurable that may indicate if you have a disease, how well a treatment is working, or if you're at risk for a future health problem.

Preliminary Qualifications

  • You are able to travel to the research center in Orlando, FL.
  • You are between 60-90 years old.
  • You have a close study partner.
Get involved

Alzheimer’s End-Of-Life Study

The purpose of this end-of-life study is to evaluate the effectiveness of a new brain (PET) scan in accurately detecting Alzheimer’s disease. We hope that earlier, more accurate detection of Alzheimer’s disease will one day allow patients to confirm their diagnosis more easily, and then they can confidently begin new treatments that may delay—or eventually even reverse—the progression of the disease.

Preliminary Qualifications

  • You are 50+ years of age.
  • You have a projected life expectancy of less than or equal to 1 year.
  • You can lay down for a brain scan (PET scan).
Get involved

Weight Loss Study

Obesity is a complex disease with many underlying causes and impacts on health. This study is to test a new drug with the potential to deliver substantial body weight reduction across the spectrum of obesity.

Preliminary Qualifications

  • You are at least 18 years of age.
  • You have a BMI greater than 35.
  • You have—or have experienced—one or more of the following: type 2 diabetes, heart attack, stroke, or peripheral arterial disease
Get involved

Schedule Your Assessment

Sign up for an initial assessment (called a “prescreen”), and we'll give you a call. One of our professional medical staff will answer your questions and give you more information about Charter Research prior to an in-office visit.

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